Small molecules may be effective therapies in neurodegenerative diseases

( testing compounds that would provide the missing link  )

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Scientists at Duke University Medical Center have found some compounds that improve a cell's ability to properly "fold" proteins and could lead to promising drugs for degenerative nerve diseases, including Huntington's disease, Alzheimer's disease and Parkinson's disease.

Misfolded proteins in nerve cells (neurons) are a common factor in all of these diseases. The Duke team has identified many new chemicals that activate a master regulator to increase the supply of "protein chaperone" molecules that help fold proteins properly.

The scientists further explored one of the candidate molecules to activate the master regulator of chaperone gene expression, Heat Shock Factor 1 (HSF1), to learn whether it would work in model systems of Huntington's disease, a devastating neurodegenerative disease of protein misfolding. The research was published in the Jan. 19 online issue of PLoS Biology. ... To  get more: http://www.eurekalert.org/pub_releases/2010-01/dumc-cth011910.php

Rosemary extract beats synthetics for edible oil preservation

A carnosic acid-rich extract from rosemary may extend the shelf-life of sunflower oil, and perform better than synthetic preservatives, says a new study... http://www.nutraingredients.com/

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