Tuesday, January 19, 2010

  To identify therapeutic targets for Alzheimer's

( a molecular tool called siRNA to screen the entire human genome  )


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A scientific group led by the Translational Genomics Research Institute (TGen) have identified three kinases, or proteins, that dismantle connections within brain cells, which may lead to memory loss associated with Alzheimer's disease.

These findings, the results of a multi-year TGen study, are published in this month's edition of BMC Genomics in a paper titled: High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.

The three kinases were found to cause a malfunction in tau, a protein critical to the formation of the microtubule bridges within brain cells, or neurons. These bridges support the synaptic connections that, like computer circuits, allow neurons to communicate with each other. ... To  get more: http://www.medicalnewstoday.com/articles/176293.php

Vitamin E may boost brain health after stroke

Tocotrienols may prevent nerve cell death in the brain following a stroke, suggests new research on this emerging form of vitamin E...  .... ...http://www.nutraingredients.com/



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