The first-generation Alzheimer's therapies

( the drug treatments towards amyloid precursor protein processing )

PleaseHelpSupport Alzheimer's Research Today!
Your Alzheimer's donation will help billionslive without it. Donate online now
The amyloid hypothesis has yielded a series of well-validated candidate drug targets with potential for the treatment of Alzheimer disease (AD). Three proteases that are involved in the processing of amyloid precursor protein-alpha-secretase, beta-secretase and gamma-secretase-are of particular interest as they are central to the generation and modulation of amyloid-beta peptide and can be targeted by small compounds in vitro and in vivo. Given that these proteases also fulfill other important biological roles, inhibiting their activity will clearly be inherently associated with mechanism-based toxicity. Carefully determining a suitable therapeutic window and optimizing the selectivity of the drug treatments towards amyloid precursor protein processing might be ways of overcoming this potential complication. Secretase inhibitors are likely to be the first small-molecule therapies aimed at AD modification that will be fully tested in the clinic. Success or failure of these first-generation AD therapies will have enormous consequences for further drug development efforts for AD and possibly other neurodegenerative conditions. To  get more: Nat Rev Neurol. 2010 Feb;6(2):99-107

Tea science stacks up for weight management

Leaf through the scientific literature and the benefits of tea, green and black, for weight managements garner much support, but more research is needed before the beverage and its extracts have “great public health importance”, says a new review. ... http://www.nutraingredients.com

Беларусь ТВ

Posted YVN