A positron emission tomography.
Alzheimer's Donation
Donate Online Now
.
A microdosing study with an investigational, carbon 11–labeled antiamyloid drug, 1,1'-methylene-di-(2-naphthol) (ST1859), and positron emission tomography (PET) in healthy volunteers (n = 3) and patients with Alzheimer's disease (n = 6).
The study aimed to assess the distribution and local tissue pharmacokinetics of the study drug in its target organ, the human brain. Before PET studies were performed in humans, the toxicologic characteristics of ST1859 were investigated by an extended single-dose toxicity study according to guidelines of the Food and Drug Administration and European Medicines Agency, which are relevant for clinical trials with a single microdose. After intravenous bolus injection of 341 21 MBq [11C]ST1859 (containing <11.4>
Alzheimer's Donation
Donate Online Now
.
A microdosing study with an investigational, carbon 11–labeled antiamyloid drug, 1,1'-methylene-di-(2-naphthol) (ST1859), and positron emission tomography (PET) in healthy volunteers (n = 3) and patients with Alzheimer's disease (n = 6).
The study aimed to assess the distribution and local tissue pharmacokinetics of the study drug in its target organ, the human brain. Before PET studies were performed in humans, the toxicologic characteristics of ST1859 were investigated by an extended single-dose toxicity study according to guidelines of the Food and Drug Administration and European Medicines Agency, which are relevant for clinical trials with a single microdose. After intravenous bolus injection of 341 21 MBq [11C]ST1859 (containing <11.4>
posted by Valery Yermalitsky at
6:23 AM
0 Comments:
Post a Comment
Subscribe to Post Comments [Atom]
<< Home