Iron-binding agents to prevent Alzheimer's disease

(new agents that are better at getting into brain cells)

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A series of iron-binding agents to prevent Alzheimer's disease has shown promising potential for getting into brain tissue. The new compounds can bind to excess iron in the brain and may prevent it from participating in the formation of abnormal protein deposits that are typically seen in the brains of patients with Alzheimer's disease.

Speaking at the Royal Pharmaceutical Society's annual event in Manchester, the British Pharmaceutical Conference, Mr Sourav Roy, from King's College, London, described tests to find new iron-binding agents capable of crossing the so-called blood brain barrier - the walls of the tiny blood capillaries to the brain which control the flow of food and chemicals into brain cells.

Iron is known to accumulate in the brains of people with Alzheimer's disease, and has been linked to the development of abnormal protein deposits - or plaques - which cause nerve damage, leading to Alzheimer symptoms, such as memory loss1. By binding to the excess iron and taking it out of the brain into the bloodstream, it is hoped that the new iron-binding agents will play a role in preventing Alzheimer's disease.

"To develop new anti-Alzheimer treatments, we need drugs that can cross the blood brain barrier, and we have discovered four new agents that are better at getting into brain cells than an iron-binding drug that is currently used to treat conditions where there is too much iron in the bloodstream," explained Roy. The four iron-binding agents will now be tested to see if they can protect nerve cells from the type of damage that occurs in Alzheimer's disease. ..http://www.medilexicon.com

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