For getting good things into the brain

(nasal sprays for Alzheimer's)

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A breakthrough discovery in the Twin Cities could make treating Alzheimer's, Parkinson's, and even traumatic brain injuries much simpler and more effective.

Dr. William Frey, a University of Minnesota Professor, founded The Alzheimer's Research Center at Regions Hospital in St. Paul. While other researchers focus on finding new drug and cell treatments, Frey discovered what could be a better way to deliver those treatments. Right now the most efficient way to get anything into the brain is through surgery. "I actually came up with this idea from a dream that I had," he said.

In the middle of the night, Frey says it struck him that poisonous gases and illicit drugs already get to the brain through the nose. "So it occurred to me if bad things can go into the brain this way, why can't we use the same route of delivery for getting good things into the brain?"

The process could potentially replace brain surgery with a simple home treatment. "I think that we will eventually see nasal sprays for these serious brain diseases like Alzheimer's, Parkinson's, head injury, stroke," explained Frey. Frey now hopes federal funding will take his research to the next level, but he's not holding his breath. "Basically, the National Institutes of Health doesn't really fund very innovative work. They like to fund things that are safe, when no one can criticize them for taking a risk," he said.

In clinical trials, Alzheimer's patients given insulin through the nose have shown improved memory and attention functions. Frey has taken it a step further, showing that stem cells have taken from a patient's own bone marrow can travel that same path—to replace damaged cells, or produce substances to help the brain heal....http://ksax.com/article/stories

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