Monday, April 06, 2009

New Alzheimer's Screening Tool
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Cellumen announced the commercial availability of a novel pharmaceutical screening technology to help discover new drugs to treat Alzheimer's disease. This technology was jointly developed by Cellumen and the Alzheimer's Drug Discovery Foundation (ADDF). ADDF provided support for the development of novel tools for drug discovery applications, including cellular models of disease and biosensors that allow for sensitive detection of the interaction between two proteins involved in Alzheimer's disease, CDK5 and p25.

When p25 interacts with CDK5, the activity of CDK5 is increased, initiating a downstream cascade that may promote tangle formation within the brains of Alzheimer's disease patients. This protein:protein interaction biosensor can be used to screen for drugs that disrupt the interaction between these two proteins. A biosensor for CDK5 and an upstream activator, p35 has also been developed to serve as a selectivity screen so that drugs that specifically target the CDK5:p25 interaction can be found. This novel biosensor has relevance to several neurodegenerative diseases associated with inappropriate regulation of CDK5 activity and tangle formation.

"Cellumen is grateful for the support of the ADDF and for the opportunity to develop products and applications for important targets that have been difficult to screen with traditional drug discovery methodology," says Kate Johnston, PhD, Chief Scientific Officer of Cellumen. "Developing novel tools for Alzheimer's disease drug discovery will have a significant impact on treatment development for the disease," said Howard Fillit, MD, Executive Director, ADDF. "Cellumen's biosensor is an important advance to the field and we are excited about the possible applications." ...http://www.medicalnewstoday.com

PROBIOTICS

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Daily consumption of broccoli sprouts may cut Helicobacter pylori infections, and offer protection against stomach ulcers, and maybe cancer, says a new study. ...http://www.nutraingredients.com

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Александр Лукашенко 6 апреля принял отставку Министра внутренних дел Владимира Наумова по состоянию здоровья, сообщила пресс-служба Лукашенко. ДАЛЕЙ





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