Drugs For Neurodegenerative Disease
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VAR10300 was tested successfully in cellular and animal models of Alzheimer's Disease (AD) reducing oxidative damage to mouse brain cells caused by iron-catalyzed free radical reactions and providing novel neuroprotective activity. The compound also improves levels of neurotransmitters, supports the growth of new neurons, and prevents cell death in preclinical models.
The lead compound, M30, was developed by Moussa B.H. Youdim, PhD, and his colleagues at the Technion Israel Institute of Technology, in collaboration with the Weizmann Institute of Science.
"We funded Professor Youdim's academic research on M30 and its derivatives for several years. We are now pleased to be able to further advance this M30-based drug development research being conducted by Varinel," said Howard Fillit, MD, ADDF's Executive Director. "The multifunctional approach shows great promise and, if successful, may yield an entirely new class of drugs for treatment of AD and other neurodegenerative diseases such as Parkinson's disease, Huntington's disease and ALS."
Varinel is one of the first biotechnology companies to receive funding through Novel Approaches to Drug Discovery for Alzheimer's Disease, a grant award program made possible by Elan. The purpose of the program is to catalyze and accelerate the discovery and development of innovative treatments for AD. Following extensive scientific review and due diligence, Varinel was selected as one of the top proposals for funding through this collaboration program. Novel Approaches has provided a total of $1,630,000 in research grants for AD research in the past three years.
"ADDF's generosity and its deep understanding of the treatment challenges associated with an Alzheimer's diagnosis has provided Varinel with both the financial and intellectual resources needed to meet our objective of bringing a unique multifunctional neuroprotective and neurorestorative anti-Alzheimer's drug into the clinic," said Dr. Vincent R. Zurawski, Jr., Varinel's President and CEO.http://www.medicalnewstoday.com
Posted YVN
The Alzheimer's Drug Discovery Foundation (ADDF) announced today that it provided a grant of $185,000 to Varinel, Inc., an emerging pharmaceutical company dedicated to developing drugs that can prevent neuronal degeneration and improve brain function. The grant will assist Varinel in advancing the preclinical development of its multifunctional lead compounds, VAR10300 (also known as M30).
VAR10300 was tested successfully in cellular and animal models of Alzheimer's Disease (AD) reducing oxidative damage to mouse brain cells caused by iron-catalyzed free radical reactions and providing novel neuroprotective activity. The compound also improves levels of neurotransmitters, supports the growth of new neurons, and prevents cell death in preclinical models.
The lead compound, M30, was developed by Moussa B.H. Youdim, PhD, and his colleagues at the Technion Israel Institute of Technology, in collaboration with the Weizmann Institute of Science.
"We funded Professor Youdim's academic research on M30 and its derivatives for several years. We are now pleased to be able to further advance this M30-based drug development research being conducted by Varinel," said Howard Fillit, MD, ADDF's Executive Director. "The multifunctional approach shows great promise and, if successful, may yield an entirely new class of drugs for treatment of AD and other neurodegenerative diseases such as Parkinson's disease, Huntington's disease and ALS."
Varinel is one of the first biotechnology companies to receive funding through Novel Approaches to Drug Discovery for Alzheimer's Disease, a grant award program made possible by Elan. The purpose of the program is to catalyze and accelerate the discovery and development of innovative treatments for AD. Following extensive scientific review and due diligence, Varinel was selected as one of the top proposals for funding through this collaboration program. Novel Approaches has provided a total of $1,630,000 in research grants for AD research in the past three years.
"ADDF's generosity and its deep understanding of the treatment challenges associated with an Alzheimer's diagnosis has provided Varinel with both the financial and intellectual resources needed to meet our objective of bringing a unique multifunctional neuroprotective and neurorestorative anti-Alzheimer's drug into the clinic," said Dr. Vincent R. Zurawski, Jr., Varinel's President and CEO.http://www.medicalnewstoday.com
Calcium L-threonate safe for use in supplements, says EFSA
The European Food Safety Authority (EFSA) has backed the use of calcium L-threonate as a source of calcium in dietary supplements. ...http://www.nutraingredients.com
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