Polyphenol-rich extract inhibits cognitive decline and Alzheimer's

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A study with rabbits indicates that extracts from pomegranate may inhibit inflammation, and positively effect chronic disease risk. The activity of cyclooxygenase enzymes associated with inflammation, COX-1 and COX-2, was inhibited in animals fed a polyphenol-rich extract of pomegranate fruit, according to results published in the open-access Journal of Inflammation. "Although direct inhibitory effect of plant extracts or components on COX enzyme activity have been reported by several investigators, inhibition of COX enzyme activity by polyphenols that become bioavailable after consumption of pomegranate fruit or extract has not been reported," wrote the researchers.

If the study can be repeated in humans it offers promise for preventing chronic inflammation, brought about by an over-expression or lack of control of the normal protective mechanism. Chronic inflammation has been linked to range of conditions linked to heart disease, osteoporosis, cognitive decline and Alzheimer's, type-2 diabetes. It is in terms of arthritis that the researchers focus their study, and indicate that pomegranate extracts could provide an alternative to use of non-steroidal anti-inflammatory drugs (NSAIDs), especially in light of mounting concerns about the adverse effects of NSAID use.

Some of these drugs, which are among the most frequently prescribed medications worldwide, have been linked with gastrointestinal toxicity, increased blood pressure, and increased risk of cardiovascular disease. "Consumption of pomegranate fruit extract may be of value in inhibiting inflammatory stimuli-induced cartilage breakdown and production of inflammatory mediators in arthritis," wrote the researchers, led by Tariq Haqqi from Case Western Reserve University in Cleveland, Ohio. Pomegranate, a rich source of antioxidants, has been linked to improved heart health, but a growing body of science indicates the fruit protect against prostate cancer. Studies have also reported a role in joint health by slowing cartilage loss in arthritis. It is these antioxidants, and particularly ellagitannin compounds like punicalagins and punicalins, which accounts for about half of the fruit's antioxidant ability, that are reportedly behind the proposed health benefits. ...http://www.nutraingredients.com

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