Nobiletin, a citrus flavonoid, improves memory

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Increasing evidence suggests that the elevation of beta-amyloid (Abeta) peptides in the brain is central to the pathogenesis of Alzheimer's disease (AD). Scientists from Tohoku University Graduate School of Pharmaceutical Sciences in their recent studies have demonstrated that nobiletin, a polymethoxylated flavone from citrus peels, enhances cAMP/PKA/ERK/CREB signaling in cultured hippocampal neurons, and ameliorates Abeta-induced memory impairment in AD model rats. They, for the first time, report that this natural compound improves memory deficits in amyloid precursor protein (APP) transgenic mice that overexpress human APP695 harboring the double Swedish and London mutations (APP-SL 7-5 Tg mice). ELISA also showed that administration of nobiletin to the transgenic mice for 4 months markedly reduced quantity of guanidine-soluble Abeta1-40 and Abeta1-42 in the brain. Furthermore, consistent with the results of ELISA, by immunohistochemistry with anti-Abeta antibody, it was evidently shown that the administration of nobiletin decreased the Abeta burden and plaques in the hippocampus of APP-SL 7-5 Tg mice. These findings suggest that this natural compound has potential to become a novel drug for fundamental treatment of AD. ... J Pharmacol Exp Ther. 2008 Jun 10

Rosemary extracts to receive antioxidant status

The European Food Safety Authority (EFSA) said rosemary extract is safe for use as an antioxidant in food, expanding application opportunities and increasing its natural appeal.

...http://www.nutraingredients.com

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