Bisdemethoxycurcumin may correct immune defects of AD patients

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Scientists from University of California and Human BioMolecular Research Institute, San Diego have tested a hypothesis that the natural product curcuminoids, which has epidemiologic and experimental rationale for use in AD, may improve the innate immune system and increase amyloid- (A) clearance from the brain of patients with sporadic Alzheimer's disease (AD).
Macrophages of a majority of AD patients do not transport A into endosomes and lysosomes, and AD monocytes do not efficiently clear A from the sections of AD brain, although they phagocytize bacteria. In contrast, macrophages of normal subjects transport A to endosomes and lysosomes, and monocytes of these subjects clear A in AD brain sections. Upon A stimulation, mononuclear cells of normal subjects up-regulate the transcription of -1,4-mannosyl-glycoprotein 4--N-acetylglucosaminyltransferase (MGAT3) (P < class="verdana10666666">

Dairy Crest to ride omega-3 trend
A third omega-3 enhanced spread is being planned by UK's Dairy Crest - a move which rubber stamps the increasing trend for food companies to take advantage of the health benefits of the fish oil.

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