The Alzheimer's vaccine

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Affitope AD01 (the Alzheimer's vaccine) from Affiris has now entered the clinical phase of its development. The trial is being run at the Vienna General Hospital and is due to be completed within one year. If it can be successfully proven that the vaccine has a positive safety and suitability profile, the second stage of the clinical development process could begin as early as next year. The aim of this stage in clinical testing would be to demonstrate the vaccine's efficacy.

The vaccine is being administered at the Vienna General Hospital (AKH) to up to 24 patients who have reached the disease stage "mild to moderate". The patients will be vaccinated four times over a period of three months, and the safety and suitability of the vaccine will be analysed over six months. Dr. Walter Schmidt, CEO of Affiris GmbH, comments on the start of the clinical phase: "We are confident that the start of our clinical trials represents a major new step in the therapy of Alzheimer's disease, an illness that still lacks a fundamentally effective treatment."

Affiris has developed the Alzheimer's vaccine from patented Affitope technology, which is based on mimotopes and allows customized vaccines to be manufactured cost-effectively. Dr. Schmidt explains the special features of Affiris' approach to the Alzheimer's vaccine: "Alzheimer's is caused by beta-amyloid, an unintentionally formed fragment of one of the body's own proteins that occurs on the surface of brain cells and has the scientific abbreviation APP. Our approach protects the brain cells and only combats the disease-causing beta-amyloid, irrespective of whether it is still present in its dissolved form in the brain fluid, or has already formed plaque deposits." Affiris specialises in the development of treatments for diseases that urgently require a medical solution and also offer attractive market potential. With 22 million sufferers predicted for 2025 and no effective treatment, Alzheimer's is one such disease.

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