Investigators confirmed PiB binds to amyloid plaques .
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A team led by Massachusetts General Hospital (MGH) investigators has confirmed that the imaging agent Pittsburgh Compound B (PiB) binds to the protein in amyloid plaques that characterize Alzheimer's disease in the human brain. Their report in the March Archives of Neurology describes the first postmortem neuropathological study of a dementia patient who had previously participated in a PET imaging study using PiB.
"This report is an essential validation of the use of PET imaging with PiB to identify amyloid-beta deposits in the brain and as a marker of disease progression that could be used to track the benefit of new treatments," says John Growdon, MD, director of the MGH Memory Disorders Unit, the paper's senior author. "It also indicates that the interpretation of PiB PET scanning needs to be done in the context of a patient's clinical symptoms and other diagnostic studies."
Alzheimer's disease is characterized by plaques within the brain of amyloid-beta protein, which is toxic to brain cells. Previous studies have shown that PiB, invented by researchers at the University of Pittsburgh School of Medicine, binds to amyloid-beta in the brains of mice and can be detected by PET scan in the brains of human patients with a diagnosis of probable Alzheimer's disease. But since a definitive Alzheimer's diagnosis can be made only on autopsy, there had been no confirmation that PiB in human brains was detecting amyloid-beta deposits.
"The distribution of amyloid seen at autopsy matched the overall distribution seen in the PiB imaging study; levels were higher in the cerebral cortex than in other areas of the brain," says Matthew Frosch, MD, PhD, of the MassGeneral Institute for Neurodegenerative Diseases (MGH-MIND), a study co-author. "Features of Alzheimer's pathology, amyloid plaques and neurofibrillary tangles, were observed, but not at a level that would support a separate diagnosis of Alzheimer's disease."
The European ice-cream sector has been stagnant for many companies due to a maturation of the sector, health concerns and growing competition from cheaper private-label products, according to analysts. As a result companies are moving into the market for more premium products and unusual combinations of flavours. Danisco's goats milk ice cream formulation is made with fresh, organic goat's milk.
Alzheimer's Donation
Donate Online Now
.
A team led by Massachusetts General Hospital (MGH) investigators has confirmed that the imaging agent Pittsburgh Compound B (PiB) binds to the protein in amyloid plaques that characterize Alzheimer's disease in the human brain. Their report in the March Archives of Neurology describes the first postmortem neuropathological study of a dementia patient who had previously participated in a PET imaging study using PiB.
"This report is an essential validation of the use of PET imaging with PiB to identify amyloid-beta deposits in the brain and as a marker of disease progression that could be used to track the benefit of new treatments," says John Growdon, MD, director of the MGH Memory Disorders Unit, the paper's senior author. "It also indicates that the interpretation of PiB PET scanning needs to be done in the context of a patient's clinical symptoms and other diagnostic studies."
Alzheimer's disease is characterized by plaques within the brain of amyloid-beta protein, which is toxic to brain cells. Previous studies have shown that PiB, invented by researchers at the University of Pittsburgh School of Medicine, binds to amyloid-beta in the brains of mice and can be detected by PET scan in the brains of human patients with a diagnosis of probable Alzheimer's disease. But since a definitive Alzheimer's diagnosis can be made only on autopsy, there had been no confirmation that PiB in human brains was detecting amyloid-beta deposits.
"The distribution of amyloid seen at autopsy matched the overall distribution seen in the PiB imaging study; levels were higher in the cerebral cortex than in other areas of the brain," says Matthew Frosch, MD, PhD, of the MassGeneral Institute for Neurodegenerative Diseases (MGH-MIND), a study co-author. "Features of Alzheimer's pathology, amyloid plaques and neurofibrillary tangles, were observed, but not at a level that would support a separate diagnosis of Alzheimer's disease."
The European ice-cream sector has been stagnant for many companies due to a maturation of the sector, health concerns and growing competition from cheaper private-label products, according to analysts. As a result companies are moving into the market for more premium products and unusual combinations of flavours. Danisco's goats milk ice cream formulation is made with fresh, organic goat's milk.
posted by Valery Yermalitsky at
6:43 AM
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