Thursday, January 18, 2007

Maintaining brain cells and synapses in good condition is critical
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Maintaining brain cells and synapses in good condition is critical, since mental performance is totally reliant on the health of the brain's complex network of trillions of synapses. Deterioration or loss of synapses can result in changes in mood and cognition, and in alterations of brain functioning such as those associated with neurological disorders or aging.

Stress is a major cause of synapse dysfunction. Research shows that prolonged exposure to stress can interfere with the function of neurotransmitters. Excessive amounts of the excitatory neurotransmitter glutamate may accumulate in the synapse. In high concentrations, glutamate becomes a toxin that can interfere with learning and cause cell damage in the brain's memory regions. Research presented at the 2006 American Psychological Association convention suggests that repeated stress remodels the brain and causes neurons in the hippocampus and prefrontal cortex to shrink. Stress can also lead to depression, which is associated with memory difficulties.

A number of studies suggest that lack of stimulation is associated with a reduced number of synaptic connections in the brain, a factor that may increase vulnerability to Alzheimer's disease (AD). For example, scientists who used an electron microscope to compare post-mortem brain tissue from the prefrontal cortex of 16 subjects found that those whose professions required greater amounts of skill or education had 17 percent more synapses for each neuron than those with less education. Another study suggests that seniors who enjoy a variety of intellectually challenging activities (such as playing a musical instrument, solving puzzles or reading) have a lower risk of developing dementia. It is thought that the larger number of neuronal interconnections associated with regular intellectual activity may provide extra insurance against cognitive decline.

The synapses are vulnerable to neurotoxins, as well. Excessive alcohol consumption, exposure to certain pesticides and heavy metals, and to drugs such as phencyclidine (PCP) and ketamine can cause memory problems and synaptic loss. The toxin from the bacteria that causes poisonous botulism acts directly on the synapses by blocking transmission of neurotransmitters, as does the deadly toxin curare.

Following these tips may help you keep your mind active and alert by protecting and strengthening your synapses:

1. Reduce stress: Make time for leisure activities. Learn relaxation techniques such as meditation. Cut down on unnecessary responsibilities and avoid over-scheduling.

2. Stimulate your brain: Avoid routine. Enjoy new sensory experiences. Challenge your mind and body with new situations.

3. Exercise: A brisk walk or other cardiovascular workout oxygenates the brain and promotes brain growth factors.

4. Challenge your mind: Tackle puzzles, games and demanding intellectual tasks. Make an effort to learn new information through classes or reading

5. Stay healthy: Eat a nutritious diet, get adequate sleep, avoid smoking, and if you use alcohol, drink in moderation.

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