The link between Alzheimer's and folic acid .
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This connection led to the 1998 introduction of public health measures in the US and Canada, where all grain products are fortified with folic acid – the synthetic, bioavailable form of folate.
After an average of 6.1 years of follow-up, 192 cases of Alzheimer's disease had been diagnosed. After adjusting for potential confounding factors, like age, sex, ethnicity, cardiovascular history and B6 and B12 intake, Luchsinger and co-workers report that increasing folate intake, from both dietary and supplemental sources, was associated with a significantly reduced risk of Alzheimer's disease (50 per cent risk reduction).
Interestingly, neither dietary folate nor supplements alone were significantly linked to Alzheimer's disease risk; only the two in combination appeared to produce an effect. Vitamin B12 and B6 levels were not associated with Alzheimer's disease risk, said the researchers.
“We found that higher folate intake was independently related to lower AD risk in a predominantly Hispanic and African American cohort of elderly persons with a high prevalence of vascular risk factors,” wrote the researchers. Higher folate intake was modestly correlated with lower homocysteine levels, "indirectly suggesting that a lower homocysteine level is a potential mechanism for the association between higher folate intake and a lower Alzheimer's disease risk," said the authors.
The link between Alzheimer's and homocysteine involves the accumulation of amyloid proteins in the brains. In vitro studies have reported that folate deficiencies and high homocysteine levels may enhance the effects of amyloid-beta, which in turn would indicate an increase in Alzheimer risk factors.
The researchers stress that no definitive conclusion about the role of folate in the development of Alzheimer's disease can be made, since the findings are at odds with previously published studies.
"Thus, the decision to increase folate intake to prevent Alzheimer's disease should await clinical trials," they concluded. Clive Ballard, director of research for British charity the Alzheimer's Society agreed that a controlled trial is necessary to “determine the full value of this research.” "It is worth noting that follow-up studies within communities are notoriously difficult to interpret because there are other external factors that can influence the results,” siad Ballard in a statement. “These latest findings add weight to growing evidence about the important role that dietary factors can play in preventing Alzheimer's disease,” he said.
The B-Vitamin Treatment Trialists' Collaboration should soon be better able to address the link between B-vitamins, homocysteine levels, and cognitive function. The effects of three to seven years of treatment with B vitamins on cognitive function should eventually be available on about 20,000 of the 50,000 participants with previous cardiovascular or renal disease from 12 large homocysteine-lowering trials.
Alzheimer's Donation
Donate Online Now
.
This connection led to the 1998 introduction of public health measures in the US and Canada, where all grain products are fortified with folic acid – the synthetic, bioavailable form of folate.
After an average of 6.1 years of follow-up, 192 cases of Alzheimer's disease had been diagnosed. After adjusting for potential confounding factors, like age, sex, ethnicity, cardiovascular history and B6 and B12 intake, Luchsinger and co-workers report that increasing folate intake, from both dietary and supplemental sources, was associated with a significantly reduced risk of Alzheimer's disease (50 per cent risk reduction).
Interestingly, neither dietary folate nor supplements alone were significantly linked to Alzheimer's disease risk; only the two in combination appeared to produce an effect. Vitamin B12 and B6 levels were not associated with Alzheimer's disease risk, said the researchers.
“We found that higher folate intake was independently related to lower AD risk in a predominantly Hispanic and African American cohort of elderly persons with a high prevalence of vascular risk factors,” wrote the researchers. Higher folate intake was modestly correlated with lower homocysteine levels, "indirectly suggesting that a lower homocysteine level is a potential mechanism for the association between higher folate intake and a lower Alzheimer's disease risk," said the authors.
The link between Alzheimer's and homocysteine involves the accumulation of amyloid proteins in the brains. In vitro studies have reported that folate deficiencies and high homocysteine levels may enhance the effects of amyloid-beta, which in turn would indicate an increase in Alzheimer risk factors.
The researchers stress that no definitive conclusion about the role of folate in the development of Alzheimer's disease can be made, since the findings are at odds with previously published studies.
"Thus, the decision to increase folate intake to prevent Alzheimer's disease should await clinical trials," they concluded. Clive Ballard, director of research for British charity the Alzheimer's Society agreed that a controlled trial is necessary to “determine the full value of this research.” "It is worth noting that follow-up studies within communities are notoriously difficult to interpret because there are other external factors that can influence the results,” siad Ballard in a statement. “These latest findings add weight to growing evidence about the important role that dietary factors can play in preventing Alzheimer's disease,” he said.
The B-Vitamin Treatment Trialists' Collaboration should soon be better able to address the link between B-vitamins, homocysteine levels, and cognitive function. The effects of three to seven years of treatment with B vitamins on cognitive function should eventually be available on about 20,000 of the 50,000 participants with previous cardiovascular or renal disease from 12 large homocysteine-lowering trials.
posted by Valery Yermalitsky at
6:32 AM
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