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Alzheimer’s Disease: New Doors Opened.
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In a recent research, US scientists have been able to pinpoint to the exact causes of Alzheimer’s disease. The research has found that Alzheimer’s disease is caused due to aging. It is caused by the brain’s inability to clean house as it gets older.
Scientists have discovered molecular janitors that clear away a gummy muck, but in the later stages of life, the janitors are not able to clean and this causes Alzheimer’s disease.
The finding helps explain why Alzheimer's is a disease of aging. The experiment was performed on a roundworm at California's Salk Institute for Biological Studies and Dr. Dillin and his team said that roundworms were used because they are commonly used in age related genetic research. It has been pointed out for the first time that a genetic link is present between aging and the onset of one of the world's most scourging brain diseases.
The accumulation of toxic protein, called beta-amyloid is the cause for Alzheimer’s. Dillin found two genes that are responsible for preventing these toxic proteins from multiplying. One gene, called HSF-1, destroys toxic protein inside cells. Another called DAF-16, herd’s toxic proteins cluttering the environment outside cells into less harmful clumps.
The study found that these genes become dormant with age. The disease makes a person lose his memory in the initial stages and later causes death. Less than 5 percent of cases are believed to be caused by a genetic defect, and the rest mysteriously appear with age.
Scientists say that the findings have opened doors for the development of drugs that will prevent build up of the toxic protein. Preliminary drug tests have started and show some effect in preventing the build up of the toxic protein. They provide some of the first steps toward new drugs that might someday boost the HSF-1 gene in humans and stop Alzheimer's in its tracks.
Scientists have discovered molecular janitors that clear away a gummy muck, but in the later stages of life, the janitors are not able to clean and this causes Alzheimer’s disease.
The finding helps explain why Alzheimer's is a disease of aging. The experiment was performed on a roundworm at California's Salk Institute for Biological Studies and Dr. Dillin and his team said that roundworms were used because they are commonly used in age related genetic research. It has been pointed out for the first time that a genetic link is present between aging and the onset of one of the world's most scourging brain diseases.
The accumulation of toxic protein, called beta-amyloid is the cause for Alzheimer’s. Dillin found two genes that are responsible for preventing these toxic proteins from multiplying. One gene, called HSF-1, destroys toxic protein inside cells. Another called DAF-16, herd’s toxic proteins cluttering the environment outside cells into less harmful clumps.
The study found that these genes become dormant with age. The disease makes a person lose his memory in the initial stages and later causes death. Less than 5 percent of cases are believed to be caused by a genetic defect, and the rest mysteriously appear with age.
Scientists say that the findings have opened doors for the development of drugs that will prevent build up of the toxic protein. Preliminary drug tests have started and show some effect in preventing the build up of the toxic protein. They provide some of the first steps toward new drugs that might someday boost the HSF-1 gene in humans and stop Alzheimer's in its tracks.
posted by Valery Yermalitsky at
6:13 AM
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