Alzheimer's study results reported.
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U.S. scientists say they've determined Alzheimer's disease is caused by aging and not the aggregates of a toxic protein.
Like most neurodegenerative diseases, Alzheimer's disease usually appears late in life. And that raised the question of whether it is a disastrous consequence of aging or if the toxic protein aggregates that cause the disease simply take a long time to form.
In a collaboration of researchers at the Salk Institute for Biological Studies and the Scripps Research Institute, scientists have shown aging is critical to its cause. Harmful beta amyloid aggregates accumulate when aging impedes two molecular clean-up crews from getting rid of those toxic species.
The finding, say the scientists, opens the door for development of drugs preventing build-up of toxic protein aggregates in the brain.
The study appears in the Aug. 10 issue of Science Express, the advanced online edition of the journal Science.
Like most neurodegenerative diseases, Alzheimer's disease usually appears late in life. And that raised the question of whether it is a disastrous consequence of aging or if the toxic protein aggregates that cause the disease simply take a long time to form.
In a collaboration of researchers at the Salk Institute for Biological Studies and the Scripps Research Institute, scientists have shown aging is critical to its cause. Harmful beta amyloid aggregates accumulate when aging impedes two molecular clean-up crews from getting rid of those toxic species.
The finding, say the scientists, opens the door for development of drugs preventing build-up of toxic protein aggregates in the brain.
The study appears in the Aug. 10 issue of Science Express, the advanced online edition of the journal Science.
posted by Valery Yermalitsky at
5:50 AM
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