Alzheimer's starts inside neurons
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Researchers said Thursday they may have found the earliest phase yet of when Alzheimer's disease begins to take hold.
Although experts have known for some time about the primary marker of the disease -- a buildup of a sticky, beta-amylid protein "plaques" between the neurons -- researchers at New York City-based Weill Medical College at Cornell University say they have found the origins of the plaques' formation.
"Our work is showing that, long before this extracellular phenomenon occurs, beta-amyloid is building up inside neurons -- specifically, on intracellular trafficking structures called multivesicular bodies," explained Gunnar Gouras, director of the Laboratory of Alzheimer's Disease Neurobiology at Weill Cornell Medical College.
"The brain cell isn't killed, but it is impaired in its function. And all of this occurs long before we see any evidence of plaque buildup outside the cell," Dr. Gouras said.
The discovery could lead to new ways to fight the disease, Gouras added.
The findings appear in the April 26 issue of the Journal of Neuroscience.

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