Early-onset Alzheimer's disease due to mutations

Please Help Support Alzheimer's Research Today!
Your Alzheimer's donation will help billions live without it. Donate online now

Mutations in the presenilin-1 gene (PS-1 gene) on chromosome 14 have recently been identified as a cause of familial early-onset Alzheimer's disease (EOAD). To our knowledge, only two German EOAD patients with mutations in the PS-1 gene have been identified thus far. Herein we report the case of a German EOAD patient with a family history of dementia and a missense mutation at codon 139 (M139V) of the PS-1 gene. The patient came to our clinic for the first time when he was 44 years old. During the following 7 years, his Mini-Mental State Examination (MMSE) score dropped from 24 to 0. Myocloni were an early neurological symptom that was already present during the first consultation. We could demonstrate that myoclonic activity was of cortical origin using a back-averaging method. Magnetic resonance imaging (MRI) revealed only slight changes in the early stage of the disease. Follow-up MRI studies showed progression of bitemporal ventricular enlargement and progressive frontal and temporal cortical atrophy. Although the majority of EOAD patients belong to the sporadic (non-genetic) type of AD, early-onset dementia, early myocloni and a familial history of AD should direct attention to the possibility of a genetic form of AD. ... Eur Arch Psychiatry Clin Neurosci. 1998;248(3):123-9

Australian regulator attacked over Ginkgo quality

The Australian Therapeutic Goods Administration (TGA) has come under attack for failing to pull contaminated versions of the herb, ginkgo biloba, from the market. ...http://www.nutraingredients.com

Беларусь ТВ

Weather Foreca

Ячмень— пшанiца

Ячмень — адна са старажытных раслiн у нашым земляробстве. Як i любая збожжавая культура, ячмень ва ўсходнiх славян сiмвалiзаваў пладаноснасць i адрадж ДАЛЕЙ Posted YVN