Dietary supplementation may delay the progression of Alzheimer's Disease

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Alzheimer disease has a complex etiology composed of nutritional and genetic risk factors and predispositions. A growing body of research indicates that nutritional deficiencies contribute to age-related cognitive decline, including that which accompanies Alzheimer disease (AD). Moreover, genetic risk factors for cognitive decline may remain latent pending age-related decline in nutrient intake. Controlled studies with mice have demonstrated that cognitive performance is subject to dietary compromise and that key dietary supplementation can alleviate and in some cases reverse the impact of dietary deficiencies on cognitive performance . This suggests the potential importance of early nutritional intervention, including preventative approaches before definitive diagnosis .
Oxidative stress is a pivotal factor in AD and is evident before cytopathologic hallmarks of the disorder . Antioxidants therefore represent a potential preventative approach . The beneficial effects of nutritional supplementation, especially that of combinatorial supplementation, are supported by a number of preclinical and clinical studies . Of interest, therefore, was to investigate the efficacy of additional combinatorial formulations on oxidative damage and cognitive function.
Moreover, genetic risk factors for cognitive decline may remain latent pending age-related decline in nutrition, suggesting the potential importance of early nutritional intervention, including preventative approaches. It was hypothesized that a combination of multiple nutritional additives may be able to provide neuroprotection. Authors demonstrate herein that dietary supplementation with a mixture of ALA, ALCAR, GPC, DHA, and PS reduced reactive oxygen species in normal mice by 57% and prevented the increase in reactive oxygen species normally observed in mice lacking murine ApoE when maintained on a vitamin-free, iron-enriched, oxidative-challenge diet. They further demonstrate that supplementation with these agents prevented the marked cognitive decline otherwise observed in normal mice maintained on this challenge diet. These findings add to the growing numbers of research indicating that key dietary supplementation may delay the progression of age-related cognitive decline. ... Nutr Res. 2009 Jan;29(1):70-4

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