Folate, vitamin B12 and homocystein associated with AD

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Recent studies suggest that vascular disease may contribute to the cause of Alzheimer disease (AD). Since elevated plasma total homocysteine level is a risk factor for vascular disease, it may also be relevant to AD. To examine the association of AD with blood levels of homocysteine, and its biological determinants folate and vitamin B12.

Case-control study of 164 patients, aged 55 years or older, with a clinical diagnosis of dementia of Alzheimer type, including 76 patients with histologically confirmed AD and 108 control subjects. Serum homocysteine, folate, and vitamin B12 levels in patients and controls at entry; the odds ratio of Alzheimer type or confirmed AD with elevated homocysteine or low vitamin levels; and the rate of disease progression in relation to homocysteine levels at entry.

Serum homocysteine levels were significantly higher and serum folate and vitamin B12 levels were lower in patients with Alzheimer type and patients with histologically confirmed AD than in controls. The odds ratio of confirmed AD associated with a homocysteine level in the top third (> or = 14 micromol/L) compared with the bottom third (< or =" 11">

Low blood levels of folate and vitamin B12, and elevated homocysteine levels were associated with AD. The stability of homocysteine levels over time and lack of relationship with duration of symptoms argue against these findings being a consequence of disease ...Arch Neurol. 1998 Nov;55(11):1449-55

Low maternal B12 levels may increase risk of defects in babies

Women with low blood levels of vitamin B12 are at increased risk of having a child with neural tube defects, according to the findings of a new study. ...http://www.nutraingredients.com

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