Alzheimer disease-type dementia after TBI

Please Help Support Alzheimer's Research Today!
Your Alzheimer's donation will help billions live without it. Donate online now

Researchers from Kinki University School of Medicine previously demonstrated the increased amyloid precursor protein (APP) immunoreactivity around the site of damage after traumatic brain injury (TBI). However, the function of APP after TBI has not been evaluated. In new study, they investigated the effects of direct infusion of an anti-APP antibody into the damaged brain region on cerebral function and morphological changes following TBI in rats. Three days after TBI, there were many TUNEL-positive neurons and astrocytes around the damaged region and a significantly greater number of TUNEL-positive cells in the PBS group compared with the anti-APP group found. Seven days after TBI, there were significantly a greater number of large glial fibrillary acidic protein-positive cells, long elongated projections, and microtubule-associated protein-2-positive cells around the damaged region in the anti-APP group compared with the PBS group found. Seven days after TBI, the region of brain damage was significantly smaller and the time to arrival at a platform was significantly shorter in the anti-APP group compared with the PBS group. Furthermore, after TBI in the anti-APP group, the time to arrival at the platform recovered to that observed in uninjured sham operation group rats. These data suggest that the overproduction of APP after TBI inhibits astrocyte activity and reduces neural cell survival around the damaged brain region, which speculatively may be related to the induction of Alzheimer disease-type dementia after TBI. ...Mol Cell Biochem. 2009 Jan 7

Probiotics may improve alcoholics’ liver health

A pilot study from Russia and the US indicates that supplements of Bifidobacterium bifidum and Lactobacillus plantarum 8PA3 may improve the health of an alcoholic’s liver. ...http://www.nutraingredients.com

Беларусь ТВ

Posted YVN

Weather Foreca

Слушать Радио Радио Столица