The Seed Extract of Cassia obtusifolia Offers Neuroprotection

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Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder and its pathological hallmarks include β-amyloid (Aβ) plaques, dystrophic neurites associated with plaques, and neurofibrillary tangles composed of hyperphosphorylated tau protein. The gradual degeneration of nerve cells and the resultant loss of specific synaptic connections in the brain is the key pathological change associated with the emergence and progression of AD, with the amygdala, hippocampus, parahippocampal, and other adjacent cortical regions being particularly susceptible to such degeneration.

The precise causative factors in neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s disease remain elusive, but mechanisms implicated comprise excitotoxicity, mitochondrial dysfunction, and in the case of AD, the amyloid beta peptide (Aβ). Current therapeutic strategies for such disorders are very limited; thus, traditional herbal medicines currently receive increased attention. The seeds of Cassia obtisufolia have long been used in traditional eastern medicine and more recently the ethanolic fraction of the seeds (COE) has been shown to attenuate memory impairments in mice. In this study, we set out to determine the effect of COE (range: 0.1 – 10 μg/ml) on calcium dysregulation and cell death models in mouse primary hippocampal cultures implicated in general neurodegenerative processes and in the pathogenesis of AD: excitotoxicity, mitochondrial dysfunction, and Aβ toxicity. It was found that treatment with COE attenuated secondary Ca2+ dysregulation induced by NMDA (700 μM), while a pre-application of COE also reduced NMDA-induced cell death. Furthermore, COE was neuroprotective against the mitochondrial toxin 3-NP (1 mM), while having no significant effect on cell death induced by incubation with naturally-secreted oligomers of Aβ (8.2 pg/ml). Collectively, these results are important for the therapeutic use of COE in the treatment of neurodegenerative disorders. http://www.jstage.jst.go.jp/article/jphs/107/4/380/_pdf

Science builds for L-carnitine and muscle ageing

Supplementation with L-carnitine may restore natural losses of the nutrient that occur naturally with age, according to a new study with rats. ...http://www.nutraingredients.com

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