Frequency of AD in the children of spouses with Alzheimer's
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Alzheimer's disease is a terminal, neurodegenerative disorder that commonly affects patients over 65 years old. "Alzheimer's disease is a common cause of dementia in the U.S. population and the leading cause of cognitive impairment in the elderly population." Additionally, because there is a strong genetic compnent to the disease, the identification of genes involved in Alzheimer's disease is an important step towards detecting others at risk for the condition. "Because Alzheimer's disease is so common in the general population, it is not uncommon for both spouses to develop the disease. Offspring of two such affected individuals would presumably carry a higher burden of these Alzheimer's disease-associated genes."
One such gene whose mutation has shown to be linked with Alzheimer's codes for the protein apolipoprotein E. The 111 couples with AD had 297 children surviving to adulthood; 22.6% of these adult children have developed AD. The risk of AD in these children increases with age, being 31.0% (58 of 187) in those older than 60 years and 41.8% (41 of 98) in those older than 70 years. Many children (79.0%) at risk in these families are still younger than 70 years, meaning that the occurrence of AD will increase in the coming years. A family history of AD beyond the parents did not change the risk of AD in the children but did reduce the median age at onset in affected children. The apolipoprotein E 4 allele played an important part in this phenomenon but did not explain all cases of AD in the children.
When both parents have AD, there is an increased risk of AD in their children beyond that of the general population. The role of family history and the specific genes involved in this phenomenon require a better definition. "The role of family history and the specific genes involved in this phenomenon require a better definition," the authors say. "Families with a significant Alzheimer's disease history may be more likely to be referred to an Alzheimer's disease research center and, thus, the present patients may be 'enriched' for a particularly Alzheimer's disease-prone subgroup. Following these families as the offspring continue to age will provide increasingly informative data." http://www.medicalnewstoday.com
One such gene whose mutation has shown to be linked with Alzheimer's codes for the protein apolipoprotein E. The 111 couples with AD had 297 children surviving to adulthood; 22.6% of these adult children have developed AD. The risk of AD in these children increases with age, being 31.0% (58 of 187) in those older than 60 years and 41.8% (41 of 98) in those older than 70 years. Many children (79.0%) at risk in these families are still younger than 70 years, meaning that the occurrence of AD will increase in the coming years. A family history of AD beyond the parents did not change the risk of AD in the children but did reduce the median age at onset in affected children. The apolipoprotein E 4 allele played an important part in this phenomenon but did not explain all cases of AD in the children.
When both parents have AD, there is an increased risk of AD in their children beyond that of the general population. The role of family history and the specific genes involved in this phenomenon require a better definition. "The role of family history and the specific genes involved in this phenomenon require a better definition," the authors say. "Families with a significant Alzheimer's disease history may be more likely to be referred to an Alzheimer's disease research center and, thus, the present patients may be 'enriched' for a particularly Alzheimer's disease-prone subgroup. Following these families as the offspring continue to age will provide increasingly informative data." http://www.medicalnewstoday.com
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posted by Valery Yermalitsky at
6:38 AM
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