Statins are probably likely to help prevent Alzheimer's
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Scientists at the University of Washington School of Medicine, in Seattle examined the brains of 110 Group Health members, aged 65 to 79, who had participated in Adult Changes in Thought (ACT) and who donated their brains for research.
The two changes in the brain that are considered the most definitive hallmarks of Alzheimer's are brain "plaques" and "tangles." After controlling for variables including age at death, gender, and strokes in the brain, the researchers found significantly fewer tangles in the brains of people who had taken statins than in those who had not. "These results are exciting, novel, and have important implications for prevention strategies," said senior co-author Eric Larson, MD, MPH, the leader of the ACT study and executive director of Group Health Center for Health Studies. "But they need to be confirmed, because ACT is not a randomized controlled trial."
A randomized controlled trial of statin treatment and brain autopsy findings would be problematic for ethical and practical reasons, said Dr. Larson. But the ACT setting made the study more rigorous than previous observational epidemiological studies, because it uses reliable automated pharmacy records, is based in a community population, and includes autopsies in people both with and without dementia.
Statins (HMG coenzyme A reductase inhibitors), include atorvastatin (Lipitor), lovastatin (Mevacor), rosuvastatin (Crestor), and simvastatin (Zocor). They are widely prescribed to lower cholesterol of people who have heart disease or are at risk for it. Randomized controlled trials are testing some statins, especially those that cross the barrier between the blood and the brain, for their ability to prevent or treat Alzheimer's disease.
"People with Alzheimer's are diverse," said Dr. Li. "Statins are probably more likely to help prevent the disease in certain kinds of people than others." Larson adds, "Someday we may be able to know more precisely which individuals will benefit from which types of statins for preventing the changes of Alzheimer's disease." http://www.medicalnewstoday.com
Pomegranate extracts may inhibit prostate cancer growth - study
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.
Alzheimer's Donation
Donate Online Now
.
Scientists at the University of Washington School of Medicine, in Seattle examined the brains of 110 Group Health members, aged 65 to 79, who had participated in Adult Changes in Thought (ACT) and who donated their brains for research.
The two changes in the brain that are considered the most definitive hallmarks of Alzheimer's are brain "plaques" and "tangles." After controlling for variables including age at death, gender, and strokes in the brain, the researchers found significantly fewer tangles in the brains of people who had taken statins than in those who had not. "These results are exciting, novel, and have important implications for prevention strategies," said senior co-author Eric Larson, MD, MPH, the leader of the ACT study and executive director of Group Health Center for Health Studies. "But they need to be confirmed, because ACT is not a randomized controlled trial."
A randomized controlled trial of statin treatment and brain autopsy findings would be problematic for ethical and practical reasons, said Dr. Larson. But the ACT setting made the study more rigorous than previous observational epidemiological studies, because it uses reliable automated pharmacy records, is based in a community population, and includes autopsies in people both with and without dementia.
Statins (HMG coenzyme A reductase inhibitors), include atorvastatin (Lipitor), lovastatin (Mevacor), rosuvastatin (Crestor), and simvastatin (Zocor). They are widely prescribed to lower cholesterol of people who have heart disease or are at risk for it. Randomized controlled trials are testing some statins, especially those that cross the barrier between the blood and the brain, for their ability to prevent or treat Alzheimer's disease.
"People with Alzheimer's are diverse," said Dr. Li. "Statins are probably more likely to help prevent the disease in certain kinds of people than others." Larson adds, "Someday we may be able to know more precisely which individuals will benefit from which types of statins for preventing the changes of Alzheimer's disease." http://www.medicalnewstoday.com
Ellagitannins from pomegranate accumulate in the prostate and may be behind the reported benefits of the fruit, suggests a new animal study from the US.
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