Once a day pill hope in Alzheimer's fight
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And until now, there's been little to offer patients that might stop the progress of the disease known as "the long goodbye".But sufferers around the world now have a glimmer of hope thanks to some Melbourne scientists who've created a pill that could delay the onset of the degenerative symptoms of the disease.
Researchers in Australia believe the drug could significantly prevent Alzheimer's developing or delay the onset of the brain disease for many years.
Tests on mice showed that levels of Beta-amyloid, also known as Abeta, dropped by 60% within 24 hours of a single dose of PBT2 and memory performance improved within five days.
Studies conducted by Professor Ashley Bush, of the Mental Health Research Institute of Victoria (MHRI), demonstrated that the drug quickly and significantly improved spatial memory, which is an important indicator of cognitive function.
The research team used a water maze test which involved the mice remembering the location of a submerged platform in order to navigate the maze.
Prof Bush said: "This data is compelling and very exciting because it shows that PBT2 not only may facilitate the clearance of Abeta from the brain or prevent its production, but more importantly may improve cognition."
Professor George Fink, head of the MHRI, said the drug could be on the market within four years. He said: "It is a major breakthrough. Though much depends on the next phase of human clinical trials, early results indicate this drug offers hope to people with Alzheimer's disease."
Human studies on the drug will begin in Sweden next month and will be followed by a major international trial next year.
Alzheimer's is a progressive and fatal brain disease. It is the most common cause of dementia and affects around 450,000 people in Britain.
Tests on mice showed that levels of Beta-amyloid, also known as Abeta, dropped by 60% within 24 hours of a single dose of PBT2 and memory performance improved within five days.
Studies conducted by Professor Ashley Bush, of the Mental Health Research Institute of Victoria (MHRI), demonstrated that the drug quickly and significantly improved spatial memory, which is an important indicator of cognitive function.
The research team used a water maze test which involved the mice remembering the location of a submerged platform in order to navigate the maze.
Prof Bush said: "This data is compelling and very exciting because it shows that PBT2 not only may facilitate the clearance of Abeta from the brain or prevent its production, but more importantly may improve cognition."
Professor George Fink, head of the MHRI, said the drug could be on the market within four years. He said: "It is a major breakthrough. Though much depends on the next phase of human clinical trials, early results indicate this drug offers hope to people with Alzheimer's disease."
Human studies on the drug will begin in Sweden next month and will be followed by a major international trial next year.
Alzheimer's is a progressive and fatal brain disease. It is the most common cause of dementia and affects around 450,000 people in Britain.
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