A low-carb diet may help stave Alzheimer's
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NEW YORK, June 14 (UPI) -- New York researchers suggest that dietary regimens such as a low-carbohydrate diet might calm or even reverse symptoms of Alzheimer's Disease.
The study, published in the July issue of the Journal of Biological Chemistry, used an experimental mouse model to demonstrate that beta-amyloid peptides in the brain can be reduced by subjecting the mice to dietary caloric restriction, primarily based on low-carbohydrate food. Conversely, a high-caloric intake based on saturated fat was shown to increase levels of beta-amyloid peptides.
"Both clinical and epidemiological evidence suggests that modification of lifestyle factors such as nutrition may prove crucial to Alzheimer's disease management," says lead author Dr. Giulio Maria Pasinetti, director of the Neuroinflammation Research Center at Mount Sinai School of Medicine and lead author of the study.
"This research, however, is the first to show a connection between nutrition and Alzheimer's disease neuropathy by defining mechanistic pathways in the brain and scrutinizing biochemical functions."
The study, published in the July issue of the Journal of Biological Chemistry, used an experimental mouse model to demonstrate that beta-amyloid peptides in the brain can be reduced by subjecting the mice to dietary caloric restriction, primarily based on low-carbohydrate food. Conversely, a high-caloric intake based on saturated fat was shown to increase levels of beta-amyloid peptides.
"Both clinical and epidemiological evidence suggests that modification of lifestyle factors such as nutrition may prove crucial to Alzheimer's disease management," says lead author Dr. Giulio Maria Pasinetti, director of the Neuroinflammation Research Center at Mount Sinai School of Medicine and lead author of the study.
"This research, however, is the first to show a connection between nutrition and Alzheimer's disease neuropathy by defining mechanistic pathways in the brain and scrutinizing biochemical functions."
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